Table 1.
Performance characteristics of different non-invasive BC tests
| Test name | Principle | Sensitivity% | Specificity% |
|---|---|---|---|
| Bladder CARE | Multiplex MSRE-qPCR | 94* | 93* |
| BTA stat | Immunoassay | 61 [23] | 78 [23] |
| Cxbladder | RT-qPCR | 91 [24] | Not reported |
| EpiCheck | Multiplex MSRE-qPCR | 63 [25, 26] | 86 [25, 26] |
| ImmunoCyt | Immunocytochemical assay | 62 [23] | 79 [23] |
| NMP22 BladderChek | Immunoassay | 58 [23] | 85 [23] |
| UroMark | Targeted bisulfite sequencing | 98 [21] | 97 [21] |
| UroVysion | Fluorescence in situ hybridization (FISH) | 72 [27] | 83 [27] |
| Cytology | 48 [23] | 86 [23] | |
| Cystoscopy (blue light) | 92 [28] | 48 [28] | |
| Cystoscopy (white light) | 81 [28] | 49 [28] |
Test type and performance characteristics of several non-invasive BC tests are summarized and compared to cytology and cystoscopy techniques
*Performance of Bladder CARE is based on the results reported in this manuscript