Table 2.

Comparison of LD₅₀ and EC₅₀ Values for MMV676477^a

compound	EC50 ± SE (nM)	LD50 ± SE (nM)	LD50/EC50 ratios
MMV676477	500 ± 20	650 ± 200	1.3
amphotericin B	65 ± 26	82 ± 7.1	1.3

^a${\text{LD}}_{50}^{72\mathrm{h}}$ concentrations for MMV676477 and the known cytocidal antileishmanial drug amphotericin in L. amazonensis intracellular amastigotes were compared to the ${\text{EC}}_{50}^{72\mathrm{h}}$ concentrations for L. amazonensis intracellular amastigotes. Shown are mean ${\text{EC}}_{50}^{72\mathrm{h}}$ and ${\text{LD}}_{50}^{72\mathrm{h}}$ values (nM) ± SE calculated from three biological replicates. Ratios are calculated by dividing the LD₅₀ by the EC₅₀ value.