Table 3.

Activity of MMV676477 against Additional Parasites^a

pathogen	MMV676477 EC50 ± SE (nM)
L. donovani axenic amastigotes	1300 ± 210
P. falciparum	420 ± 19
L. tarentolae axenic amastigotes	11 ± 1.3
T. brucei	190 ± 8.7
Neospora caninumb	13
Cryptosporidium parvumb	220
Entamoeba histolytica trophozoite proliferation at 10 μMb	56%

^a${\text{EC}}_{50}^{72\mathrm{h}}$ values for MMV676477 against L. donovani axenic amastigotes, blood-stage P. falciparum, and T. brucei. Shown are mean ${\text{EC}}_{50}^{72\mathrm{h}}$ values (nM) calculated from three biological replicates ± SE.

^bData obtained from literature.^26-28