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. 2021 Apr 7;12:653836. doi: 10.3389/fimmu.2021.653836

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Copyright © 2021 Xiang, Li, Shen, Zhao, Wu, Li, Yang, Kaboli, Du, Zheng, Wen, Cho, Yi and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Screening and verification of prognostic genes in HCC. (A) Least absolute shrinkage and selection operator (LASSO) regression analysis was used to screen for genetic variables. The dotted line indicates the number of genes after screening. (B) Multivariate Cox regression analysis was used to further screen genes that can be used as independent prognostic factors. The value, p < 0.5 was considered statistically significant. (C) Survival verification of the three selected genes by Kaplan–Meier plotter database in HCC. Prognostic indicators include overall survival (OS), progression-free survival (PFS), relapse-free survival (RFS), disease-specific survival (DSS).