Table 4.

Costs of reagents for sequencing and genotyping options

Depth/array	Reagent cost per sample
30×	$1,320.83
20×	$880.55
6×	$264.17
Omni2.5	$184.43
4×	$176.11
MEGA Global	$119.00
2×	$88.06
PsychChip	$71.38
GSA	$49.00
1×	$44.03
0.5×	$22.01

We aggregated the prices for reagents from Illumina’s website as of April 10, 2020. These prices notably do not include sample and library preparation costs, which we assume to be comparable between GWAS arrays and sequencing approaches. The H3Africa array is not commercially listed on Illumina’s site and is thus not included here. Sequencing reagent costs use Illumina’s list price for the NovaSeq 6000 S4 Reagent Kit. Each flow cell has a maximum output of 3,000 Gb. Prices listed assume single flow cell purchasing, which is listed at $31,700. Prices adjusting for bulk flow cell purchasing from Illumina are shown in Table S6. Sequencing costs assume 125 Gb to achieve a target depth of 30× whole-genome sequencing coverage.