Figure 5.

An integrated approach to assigning confidence scores to candidate-gene estimates

(A) Gene-prioritization evidence compiled for 342 combinations of locus-by-disease association signals across 191 unique loci and 15 autoimmune diseases. Detailed information about each locus and fine-mapping evidence are included in Table S8.

(B) This heatmap shows the frequency of at least one overlapping gene when the same locus-by-disease combination was dissected via multiple strategies. Results were plotted for pairwise strategies that co-dissected at least five locus-by-disease combinations.

(C) This heatmap shows the frequency of at least one overlapping gene when the same autoimmune disease locus was dissected via multiple strategies. Results were plotted for pairwise strategies that co-dissected at least five autoimmune-disease loci.

(D) Integration of gene-prioritization approaches to calculating confidence scores.

(E) Top 25 prioritized genes when each autoimmune disease was considered individually (i.e., gene prioritization evidence of each disease was integrated separately even when multiple autoimmune diseases had GWAS signals and genes prioritized in the same locus).

(F) Top 25 prioritized genes from disease agnostic analysis where gene-prioritization evidence across all autoimmune diseases was considered jointly in shared loci. Gene and disease names are sorted by alphabetical order. Abbreviations are as follows: CD, Crohn disease; IBD, inflammatory bowel disease; JIA, juvenile idiopathic arthritis; MS, multiple sclerosis; PSO, psoriasis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; SS, systemic sclerosis; T1D, type 1 diabetes; and UC, ulcerative colitis.