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. 2021 Apr 7;10:595527. doi: 10.3389/fonc.2020.595527

Figure 3.

Figure 3

High TMB predicted longer PFS than low TMB. Among 31 patients, 30 patients were included since the clinical information of 1 patient was incomplete. (A) The association of TMB with gender and PFS. Different colors represent relative PFS values. The triangle represents males, and the circle represents females. Patients with PFS>400 days were selected in PFS-Long group (n=16), PFS<400 days selected in PFS-Short group (n=12), two patients with incomplete PFS information selected in unknown group (n=2). (B) Improved PFS in patients with high TMB. TMB was stratified with 3rd quartile as cutoff=2.565. P value was calculated using log-rank test (P = 0.04). (C) The percentage of PFS-Long in TMB-High (n=8) and TMB-Low (n=22) groups (P = 0.003, Fisher’s exact test). (D) Violin plot comparing the difference in TMB between PFS-Long (n=16) and PFS-Short (n=12) groups. P value was calculated in two tailed Mann Whitney U test (P = 0.002). (E) Improved PFS in patients with high TMB and Stage II. Patients were stratified by the combination of Stage and TMB. TMB-High-Stage II (n=8), TMB-High-Stage III (n=0), TMB-Low Stage II (n=14), TMB-Low Stage III (n=8). P-value was calculated using log-rank test (P =0.001). The numbers in parentheses represent the number of patients in each group.