Table 3. Studies on the role of simvastatin in the treatment of vitiligo.

RCT: randomized controlled trial; Nrf2: nuclear factor erythroid 2-related factor 2

Author	Year	Type of study	No. of patients	Purpose of study	Conclusion
Chang et al. [8]	2017	In-vitro experiment	-	To study the protective role of simvastatin against oxidative stress on human melanocytes	Defends against oxidative stress by stimulating Nrf2
Niezgoda et al. [10]	2019	RCT	24	To study the influence of simvastatin in vitiligo	-
Vanderweil et al. [33]	2017	RCT	15	To investigate the role of simvastatin in the treatment of vitiligo	Oral form may not be beneficial in the treatment of vitiligo
Zhang et al. [34]	2021	RCT	5	To assess the efficacy of simvastatin in the treatment of vitiligo	Oral simvastatin is safe but may not be effective in the treatment of vitiligo
Noel et al. [35]	2004	Case report	1	To assess the role of high-dose simvastatin as an immunomodulator in vitiligo	Simvastatin can be used as an immunomodulator in vitiligo