Figure 3.

Relationships between social support, social isolation, problem drinking, and the rsFC of the Hipp/Hypo and MFG/VS. (A) Path analysis showed that social support (MSPSS) decreased Hipp/Hypo connectivity and increased MFG/VS connectivity. Hippo/Hypo connectivity was associated with heightened PB and drinking severity, whereas MFG/VS connectivity exhibited the opposite effects. Red and blue arrows indicate positive and negative relationships, respectively. Solid and dotted lines indicate significant and near-significant path coefficients, respectively. (B–D) Greater strength of Hipp/Hypo relative to MFG/VS connectivity was associated with lower social support, higher sense of isolation, and greater degree of problem drinking. *P < .01, **P < .001.