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. Author manuscript; available in PMC: 2021 Apr 21.
Published in final edited form as: J Anal Pharm Res. 2021 Mar 4;10(1):41–48. doi: 10.15406/japlr.2021.10.00364

Figure 2.

Figure 2

The fragment of MYO7A homology model showing the motor domain (residues 1-786) obtained using homology modeling and global mutagenesis. Protein domains are colored using foldability parameter, protein unfolding was evaluated from global computational mutagenesis (17). The foldability parameter changes from 0-20 and is shown by the colored bar. The maximum value of the foldability parameter (red) corresponds to the residues critical for protein stability when mutated to any amino acid (18, 19). Low foldability (dark blue) corresponds to residues, which are not critical for protein stability.