Table 1.

Myo7A domains and domain functions

Domain name	Domain function
Motor domain	Movement of MYO7A protein on actin filaments is enabled by the motor domain. The motor domain interacts with ATP and that translates into production of mechanical energy.
IQ1-IQ5 motifs	The CamIQ region regulate the function of motors in a Calcium (Ca2+)-regulated manner and acts as the lever of myosin arms.
Coiled coil	The coiled-coil region assists in the MYO7A dimer formation.
MyTH4 and FERM domains	An N-terminal proline-rich region precedes both MyTH4 and the FERM domains. F1, F2, and F3 lobes are present in each FERM domain. These lobes are known to interact with various membrane integral proteins and in connecting the cytoskeleton to the plasma membrane of the cell.
SH3	SH3 domain helps in recruiting Arp2/3 complexes, which regulates the actin cytoskeleton. C-terminal proline-rich regions of Myo7A can interact with the SH3 domain.