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. 2021 Apr 7;15:647974. doi: 10.3389/fnins.2021.647974

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Copyright © 2021 Aikawa, Ren, Holm, Asmann, Alam, Fitzgerald, Bu and Kanekiyo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of ABCA7 haplodeficiency and peripheral LPS stimulation on mouse cortical metabolomes. (A) The correlation between metabolite module eigengenes and the four groups of mice: (1) control with LPS administration, (2) Abca7^± with LPS administration, (3) control with LPS administration, and (4) Abca7^± with LPS administration. Each module is represented with a unique color. The module traits were correlated with the four groups of mice (1–4). The corresponding correlations and P-values are displayed in each module. (B,C) The interactions of top 30 hub metabolites within the lightgreen (B) and paleturquoise (C) modules were visualized. (D) Pathway analysis of metabolites using the KEGG database. Pathways in the lightgreen (B) and paleturquoise (C) modules are shown (raw p-value < 0.05).