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. 2021 Apr 7;12:642197. doi: 10.3389/fmicb.2021.642197

FIGURE 3.

FIGURE 3

Multivariable results from metagenomic sequencing (species level taxa and MetaCyc pathways). Heat maps showing the direction and size of model coefficients as determined by MaAsLin2 modeling (A) significant taxonomic differences and (B) significant functional pathways that differed relative to VD-EBF at 6 weeks and relative to VD-≥6BF at 1 year. Figures include identified taxa with a FDR corrected q value < 0.25. VD-EBF, vaginally delivered and EBF; VD-FF, vaginally delivered and FF; CD-EBF, cesarean -delivered and EBF; CD-FF, cesarean -delivered who were FF; VD- ≥ 6BF, vaginally delivered who breast-fed for >6 months; VD- < 6BF, vaginally delivered who never breast-fed or breast-fed for <6 months; CD- ≥ 6BF, cesarean -delivered who breast-fed for ≥6 months; CD- ≥ 6BF, operatively delivered who never breast-fed or breast-fed for <6 months; FDR, false discovery rate. TRNA-CHARGING-PWY, tRNA charging; THRESYN-PWY, superpathway of L-threonine biosynthesis; PWY66-422, D-galactose degradation V (Leloir pathway); PWY0-1298, superpathway of pyrimidine deoxyribonucleosides degradation; PWY0-1297, superpathway of purine deoxyribonucleosides degradation; PWY0-1296, purine ribonucleosides degradation; PWY-922, mevalonate pathway I; PWY-7383, anaerobic energy metabolism; PWY-724, superpathway of L-lysine, L-threonine and L-methionine biosynthesis II; PWY-7237, myo-, chiro- and scillo-inositol degradation; PWY-7199, pyrimidine deoxyribonucleosides salvage; PWY-6317, galactose degradation I; PWY-5676, acetyl-CoA fermentation to butanoate II; PWY-5347, superpathway of L-methionine biosynthesis;PWY-5100, pyruvate fermentation to acetate and lactate II; PWY-5030, L-histidine degradation III; PWY-4981, L-proline biosynthesis II (from arginine); PWY-4242, pantothenate and coenzyme A biosynthesis III; PWY-2941, L-lysine biosynthesis II; PENTOSE-P-PWY, pentose phosphate pathway; P164-PWY, purine nucleobases degradation I; P161-PWY, acetylene degradation; NON-OXIPENT-PWY, pentose phosphate pathway; METSYN-PWY, L-homoserine and L-methionine biosynthesis; MET-SAM-PWY, superpathway of S-adenosyl-L-methionine biosynthesis; LACTOSECAT-PWY, lactose and galactose degradation I; GOLPDLCAT-PWY, superpathway of glycerol degradation to 1,3-propanediol; COA-PWY, coenzyme A biosynthesis I; CALVIN-PWY, Calvin-Benson-Bassham cycle.