Skip to main content
. 2021 Apr 21;7(17):eabf4865. doi: 10.1126/sciadv.abf4865

Fig. 3. Fxr-Shp ablation results in hyperbranched glycosylations of liver proteins.

Fig. 3

LDKO liver glycoproteins were isolated and analyzed for their glycan profiles. LDKO livers display increased percentage of (A) core fucosylated and (B) triantennary glycans in LDKO liver compared to controls (n = 5 mice averaged per group). (C) Gene Ontology analysis of proteins with increased glycosylation reveals their cellular localization and function (n = 5 livers pooled per group). (D) Relative ratio of complex, sialylated and fucosylated glycoforms for CATZ, EMPL, and lysosomal membrane protein 2 (LAMP2) indicate enrichment of hyperglycoforms in LDKO livers compared to controls (n = 5 mice averaged per group).