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. 2021 Apr 21;7(17):eabe0143. doi: 10.1126/sciadv.abe0143

Fig. 4. Delivery of NPs to an inflamed mesentery endothelium as a function of loading into hydrogel MPs.

Fig. 4

(A) Representative bright-field and fluorescence images of particle adhesion to inflamed mesentery. n/a, not applicable. (B) Quantified adhesion density of three different particle conditions, 15% PEG, low loading hydrogel MPs, 15% PEG, high loading hydrogel MPs, and free NPs. Particles were dosed by equivalent NP payload. (C) Data scaled to the number of NPs delivered by adherent hydrogel MPs to show the efficiency of NP delivery by each VTC system. N = 3 mice per group, and statistical analysis was performed using one-way ANOVA with Fisher’s LSD test, where (**) indicates P < 0.01 and (***) indicates P < 0.001 compared to the low NP–loaded 15% PEG. Error bars plot SE. Scale bar, 50 μm.