Skip to main content
. 2021 Apr 13;2021:6650966. doi: 10.1155/2021/6650966

Figure 1.

Figure 1

Expression profiles for highly significant miRNAs. We analyzed nCounter miRNA Expression Assay Panel measurements for 800 miRNAs using t-tests to discover differences in expression between samples of subjects with CIN 3 (n = 20) and those of healthy female subjects (HFS) (n = 11). Nine miRNAs displayed statistically significant results (p < 0.05, fold change ≥ 2, and AUC ≥ 0.75). Samples are arranged in columns, miRNA expression levels in rows, and both are hierarchically clustered using Euclidean distance with the average linkage of nodes. Red shades indicate increased relative expression; green shades indicate reduced expression; black indicates median expression. The bars above indicate the groups and subgroups used for the analysis. Green indicates the samples from the HFS and the purple subgroup of the CIN 3 group. Black indicates the subgroup hr-HPV positive, and hr-HPV negative is grey.