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. 2021 Apr 21;11:8665. doi: 10.1038/s41598-021-88088-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Performance and swimming strategies in the Morris water maze test in sham, non-epileptic, and epileptic animals at week 9. (A) Performance in the Morris water maze test. No differences were observed in the time to find the platform (in seconds) during Morris water maze training days at week 9 of the experiment between sham (n = 12), non-epileptic (n = 8), and epileptic (n = 7) animals (a1) (mean ± SD). (B) Analysis of swimming strategy on the Morris water maze test day using RODA software. The epileptic group (n = 7) exhibited a decrease in the number of sections where they presented a scanning (SC) strategy at week 9 compared with the sham group (n = 12). *p < 0.05 (mean ± SEM). (C) Comparison of scanning and incursion strategies in the Morris water maze. A higher proportion of scanning (SC) to incursion (IC) was observed in the sham group (n = 12) compared with the epileptic group (n = 7) at week 9. *p < 0.05 (c1, c3). No differences were observed between sham and non-epileptic animals (n = 8) (c1, c2) (mean ± SD).