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. 2021 Apr 21;12:2356. doi: 10.1038/s41467-021-22593-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Principal component analyses (PCA) of all nine transcriptional biomarkers in forepaw skin biopsies on twelve-month-old animals. Note little to no overlap between WT ctr.sh (gray, n = 7) and CMT1A ctr.sh (red, n = 8), whereas the treated groups, CMT1A sh1 (blue, n = 7) and CMT1A sh2 (green, n = 7), show more overlap with the WT ctr.sh group than with the CMT1A ctr.sh group. The mean of each group is given as a center point including the confidence interval (95%) given as an ellipse. b Correlation matrix from all animals (total n = 28 with n = 7 per group) including the expression levels of the skin biomarkers (green labels) and the four functional phenotypic analyses (purple labels): GS, grip strength; NCV, nerve conduction velocity; ROD, Rotarod; RST, Randall-Selitto test). Shown is data from a two-sided Pearson’s correlation analyses with graphical representation of the correlation coefficients, from red (−1) to blue (+1) (indicated by circle size and color), and the respective p-values (asterisks indicate p < 0.05, all the exact p-values are available in the Source Data File). c Principal component analyses (PCA) of the three best biomarkers (Nrg1-I, Gria1, Cda; see correlation matrix in b) in forepaw skin biopsies on twelve-month-old animals (same analysis as in a). Source data are provided as a Source Data file.