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. 2021 Apr 21;11:8584. doi: 10.1038/s41598-021-88017-w

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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DiR-NPs targeting in Ang II mouse model. (a) In-vivo targeting study using DiR loaded nanoparticles (DiR-NPs). DiR NPs were injected via tail vein and after 24 h animals were euthanized d to assess the targeting. The signal given by the DiR-NPs in the IVIS images (a2,a3) indicated that DiR-NPs only accumulate at the suprarenal aortic area where the aneurysm developed (a1), suggesting the successful targeting of the nanoparticles to the aneurysmal tissue; (b) VVG staining of the aneurysmal tissue showing elastin damage and (c) fluorescent image of the same site showing distribution of the DiR-NPs (purple) within the tissue, indicating that DiR-NPs target the degraded elastin (green autofluorescence) in the aneurysm.