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. 2021 Apr 21;11:8584. doi: 10.1038/s41598-021-88017-w

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Histological analysis. (a,b) H&E staining for aneurysms; BLN-NPs, control and PGG-NPs groups are at lower (a1–4) and higher (b1–4) magnifications, showing the morphology and the cell infiltration of the suprarenal aortic tissue. The PGG-NPs group had better morphology and minimal cell infiltration compared to the other groups (the opening shown in a4 and d4 was a vessel branching out from the aorta); (c,d) VVG staining for aneurysms; BLN-NPs, control and PGG-NPs groups are at lower (c1–4) and higher (d1–4) magnifications, showing the elastin damage within the tissue. The elastic laminae in the PGG-NPs were repaired as compared to before therapy while in other groups they continued to degrade.