Table 3.
Demographic characteristics and factors associated with HBV infection in the 2-year follow-up phase, Nha Trang, Vietnam, 2011–2012 (N = 1339).
| Factors | Total N (%) | HBV infection in children n (% n/N) | OR (95%CI) | aOR (95%CI) |
|---|---|---|---|---|
| N = 1339 | n = 26 (1.9%) | |||
| [Children] | ||||
| HBsAg | ||||
| Negative | 1313 (98.1) | |||
| Positive | 26 (1.9) | |||
| Anti-HBs antibody (mIU/ml) | ||||
| < 10 | 203 (15.2) | 12 (5.9) | Ref | Ref |
| 10–99 | 615 (46.0) | 9 (1.5) | 0.2 (0.1, 0.6) | 0.2 (0.1, 0.7) |
| ≥ 100 | 520 (38.9) | 5 (1.0) | 0.2 (0.1, 0.4) | 0.1 (0.04, 0.4) |
| Sex | ||||
| Female | 639 (47.7) | 15 (2.4) | Ref | - |
| Male | 700 (52.3) | 11 (1.6) | 1.5 (0.7, 3.3) | - |
| Immunization status of HepB | ||||
| No or Incomplete | 315 (23.5) | 10 (3.2) | Ref | |
| Complete | 1024 (76.5) | 16 (1.6) | 0.5 (0.2–1.1) | - |
| Timing of HepB-BD | ||||
| No | 229 (17.1) | 6 (2.6) | Ref | - |
| Day 0–1 | 1104 (82.5) | 20 (1.8) | 0.7 (0.3, 1.7) | - |
| Day 2–7 | 6 (0.5) | 0 (0) | * | - |
| HBIG at birth | ||||
| No | 1333 (99.8) | 25 (1.9) | Ref | Ref |
| Yes | 3 (0.2) | 1 (33.3) | 26.2 (2.3, 298.0) | 10.3 (0.8, 133.9) |
| [Mothers] | ||||
| HBsAg | ||||
| Negative | 1173 (87.6) | 1 (0.1) | Ref | Ref |
| Positive | 166 (12.4) | 25 (15.1) | 207.8 (27.9, 1545.3) | 217.4 (28.6, 1651.5) |
| Age (years old) | ||||
| 17–24 | 385 (28.9) | 11 (2.9) | Ref | - |
| 25–34 | 769 (57.8) | 14 (1.8) | 0.6 (0.3, 1.4) | - |
| 35–44 | 177 (13.3) | 1 (0.6) | 0.2 (0.02, 1.5) | - |
| BMI in prepregnancy | ||||
| Normal-High | 997 (74.5) | 12 (1.2) | Ref | Ref |
| Low | 342 (25.5) | 14 (4.1) | 3.5 (1.6, 7.7) | 4.9 (1.9, 12.6) |
| Mode of delivery | ||||
| Vaginal | 766 (57.2) | 18 (2.4) | Ref | - |
| Caesarian Section | 573 (42.8) | 8 (1.4) | 0.6 (0.3, 1.4) | - |
Logistic regression was used for projecting odds ratios (OR) in univariate analysis and adjusted odds ratios (aOR) in multivariate analysis.
Variables with statistical significance were underlined where 95%CI of aOR did not include 1.
HBsAg: hepatitis B surface antigen; HBV: hepatitis B virus; anti-HBs antibody: anti-hepatitis B surface antibody; N: number; OR: odds ratio; CI: confidence interval; aOR: adjusted odds ratio; HepB: hepatitis B vaccine; HepB-BD: birth dose of HepB; incl.; including; w/o: without; HBIG: hepatitis B immune globulin; BMI: body mass index; and Ref.: reference.
*Dropped since no HBsAg-positive cases existed in the category.