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. 2021 Apr 21;11:8604. doi: 10.1038/s41598-021-88013-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Inflammatory T-cell subsets in BSRC blood. (A) CD4⁺ and (B) CD8⁺ CD45RA⁻ central and effector memory T cells were used to gate CCR6⁺ and CCR6⁻ fractions. CCR6⁻ cells were further distinguished in T1, based on CXCR3 expression or T2, based on CCR4 expression. CCR6⁺ cells were distinguished in T17.1, based on CXCR3 expression and T17 and T22 subsets were gated based on CCR4 and CCR10 expression. (C) Lines show median frequencies of CD4⁺ T_H1, T_H2, T_H17.1, T_H17 and T_H22 T-cell subsets of controls and active/inactive BSRC patients. (D) The frequencies of T_H1 and T_H2 fractions were used to calculate a T_H1/T_H2 ratio. (E) Lines show median frequencies of CD8⁺ T_C1, T_C2, T_C17.1, T_C17 and T_C22 T-cell subsets. (F) Volcanoplot (− log10) shows Spearman’s Rho correlation coefficient of immunological versus clinical parameters of T_H1, T_H2, T_C1, T_C2 T-cell populations and T_H1/T_H2 ratio of BSRC patients. BSRC birdshot retinochoroiditis, CM central memory, CME cystoid macula edema, CRT central retinal thickness, EM effector memory, N naïve, T_C cytotoxic T cell, T_H T-helper, TEMRA terminally differentiated effector memory CD45RA⁺.