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. 2021 Apr 21;11:8626. doi: 10.1038/s41598-021-88133-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Tiliroside restrained the 3D formation ability and CD133 expression of Hep3B and SNU-449 cells. The representative 3D spheroid models of Hep3B (A) and SNU-449 (B) cells treated by 40 μM Tiliroside and NC. The relative cross-section area formation efficiency showed significant reduction of area of Hep3B (C) and SNU-449 (D) in Tiliroside groups. Relative inhibition rates of Hep3B and SNU-449 in response to Tiliroside were calculated by comparing the fluorescence value of Tiliroside to NC, at 24, 48, 72, 96 and 120 h, respectively (E). Tiliroside (40 μM) treatment significantly reduced the CD133 relative expression levels in both 3D cultured Hep3B and SNU-449 cells (P < 0.001) (F). NC negative control.