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. 2021 Apr 21;11:8666. doi: 10.1038/s41598-021-87939-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Therapeutic efficacy of EVs in a mouse model of MI. (A) Schematic overview of the in vivo MI mouse model. Figure was generated using Microsoft PowerPoint (https://www.microsoft.com/en-us/microsoft-365/powerpoint); i.m.: intramuscular. (B) Percent change in ejection fraction (ΔEF) between days 28 and 1 post-MI. (C) Representative images of Masson’s trichrome staining. (D) Quantitative analysis of scar size in (C). (E) Quantitative analysis of infarct wall thickness (IWT) in (C). Results are depicted as mean ± SEM. Statistical significance was determined using 1-way ANOVA followed by Tukey’s multiple comparisons test. *P < 0.05.