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. 2021 Apr 21;11:8669. doi: 10.1038/s41598-021-88159-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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mRNA expression profile of Tnnt2^high and Tnnt2^low cardiomyocytes from Wild type and Glut1 transgenic hearts at P1. (a) Representative dot plot of flow cytometry analysis of P1 Wild type hearts for Tnnt2 (cardiac marker) and Mitotracker (mitochondrial contents). Note two populations of cardiomyocytes. (b) Flow cytometry analysis of P1 aMHC-Cre ^tg; R26^{+/YFP reporter} and aMHC-hGLUT1 ^tg; aMHC-Cre ^tg; R26^{+/YFP reporter} analysis for YFP (cardiac lineage) and Mitotracker (mitochondrial contents). Note two populations of cardiomyocytes. (c) Venn diagram of mRNA expressed in Tnnt2^high and Tnnt2^low cardiomyocytes from Wild type and Glut1 transgenic hearts. Bar graphs represent top three gene ontology (GO) term enriched in the genes uniquely expressed in each population. Although 4 populations are similar, G1 Tnnt2^low cardiomyocytes are enriched for the genes associated with mitosis, cell cycle, and cell division. (d) GO analysis of the genes upregulated in Glut1 tg Tnnt2^low vs Glut1 tg Tnnt2^high. (e) Heatmap of expression level of representative cardiac, cell cycle, and mitochondrial genes differentially expressed in Glut1 tg Tnnt2^low vs Glut1 tg Tnnt2^high.