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. 2021 Apr 21;11:8669. doi: 10.1038/s41598-021-88159-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Tnnt2^low cardiomyocytes are mitotically activated by the increase in intracellular glucose. (a) Representative flow cytometry profile of the ventricular cardiomyocytes from P7 Wild type and Glut1 transgenic hearts stained with Tnnt2 and Mitotracker. (b) Representative flow cytometry plot of EdU incorporation assay of Tnnt2^low cardiomyocytes. Wild type and Glut1 transgenic mice were injected with EdU and the ventricular cardiomyocytes were isolated and analyzed by Tnnt2, Mitotracker, and EdU staining. (c) Mitotic index of Tnnt2^high and Tnnt2^low cardiomyocytes in Wild type and Glut1 transgenic heart with or without injury. n = 3–8. *p < 0.05. ***p < 0.001. Note that Tnn2^low cardiomyocytes are more mitotic than Tnn2^high cardiomyocytes and that the mitotic activity of Tnnt2^low cardiomyocytes drastically increases in Glut1 transgenic background.