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. 2021 Apr 21;11:8669. doi: 10.1038/s41598-021-88159-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Metabolomics analysis of Glut1 transgenic hearts. (a) Metabolomics analysis of Glut1 transgenic hearts and wild type litters at P2 pre-injury and post-injury and P7 post-injury. At P2 stage, overall, the metabolic profile shows no drastic difference at the basal level, but glucose utility increases upon injury as represented by the increase in the metabolites in polyol pathway and glucose. At P7 stage, the metabolic profile showed a statistical differences of intermediates in the Pentose Phosphate Pathway. n = 3 wild type, n = 6 Glut1 tg hearts. *p < 0.05. **p < 0.01. (b) Histological analysis of glycogen storage of Glut1 transgenic hearts and its controls from wild type litters at P2, P4 and P7 by Periodic Acid Staining. Representative images of 3 samples in each group. Scale bar = 200 µm and 20 µm respectively. (c) Glycogen quantification by colorimetric assay kit at P2, P4 and P7 stage. n = 3 per group. *p < 0.05. **p < 0.01. Note the increased intracellular glycogen storage in Glut1 transgenic hearts.