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. 2021 Apr 21;11:8669. doi: 10.1038/s41598-021-88159-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Impact of hydroxyurea on the proliferation of Tnnt2^low cardiomyocytes. (a) Representative contour plots (left) for Tnnt2 and Mitotracker and dot plots (right) for EdU and DNA content by flow cytometry analysis at P7. Wild type and Glut1 transgenic hearts were cryoinjured at P1 and treated with daily injection of HU or vehicle until the analysis at P7. (b) Quantification of %EdU positive cells in Tnnt2^high and Tnnt2^low cardiomyocytes in wild type and Glut1 transgenic hearts with or without HU treatment. Note that both Tnnt2^high and Tnnt2^low cardiomyocytes respond to HU treatment but that EdU incorporation of Tnnt2^low cardiomyocytes was drastically decreased by HU treatment. n = 4. ***p < 0.01. (c) Quantification of the Tnnt2^high and Tnnt2^low fractions of cardiomyocytes in wild type and Glut1 transgenic hearts with or without HU treatment. While Tnnt2^high or Tnnt2^low fractions was not influenced by HU in wild type heart, HU treatment significantly decreased the percentage of Tnnt2^low cardiomyocytes in Glut1 transgenic hearts. n = 4. **p < 0.01. ***p < 0.001.