TABLE 1.

Known and putative functions of transgelin-2 in immune and cancer cells.

System	Cell types	Expression	Functions or results	References
Immune system	Helper T cells	Constitutive	Immunological synapse; T-cell activation	Na et al., 2015
	Cytotoxic T cells	Constitutive	Adhesion to target cells; Increased tumor cell killing	Na and Jun, 2015; Jeon et al., 2018
	B cells	Constitutive/Inducible*	Immunological synapse; T-cell activation	Francés et al., 2006; Na et al., 2015, 2016
	Macrophages	Inducible*	Increased phagocytic function; Reduced mortality against bacterial infection	Kim et al., 2017
Cancer	Colorectal cancer	Upregulated**	Tumorigenesis	Ali et al., 2010; Zhang et al., 2010; Yoshino et al., 2011
	Cervical cancer	Upregulated	Tumorigenesis	Yakabe et al., 2016
	Lung cancer	Upregulated	Tumorigenesis	Moriya et al., 2012
	Gastric cancer	Upregulated	Tumorigenesis	Xu et al., 2014
	Hepatic cancer	Upregulated	Tumorigenesis	Huang et al., 2006
	Renal cancer	Upregulated	Tumorigenesis	Kawakami et al., 2012
	Pancreatic cancer	Upregulated	Tumorigenesis	Lin et al., 2013
	Bladder cancer	Upregulated	Tumorigenesis	Yoshino et al., 2011
	Prostate cancer	Upregulated	Tumorigenesis	Jie et al., 2009
	Esophageal cancer	Upregulated	Tumorigenesis	Du et al., 2016
	Oral cancer	Upregulated	Tumorigenesis	Kawahara et al., 2016
	Head and neck SCC	Upregulated	Tumorigenesis	Nohata et al., 2011a,b
	Meningiomas	Upregulated	Tumorigenesis	Sharma et al., 2015
	Lymphoma and leukemia	Upregulated	Tumorigenesis	Gez et al., 2007
	Breast cancer	Upregulated	Paclitaxel resistant MCF-7/PTX cells	Zheng et al., 2015
	Choriocarcinoma	Upregulated	Methotrexate-resistant JAR/MTX cells	Chen et al., 2004
	Breast cancer	Downregulated	Highly metastatic MDA-MB-231HM cells	Xu et al., 2010
	Cervical cancer	Downregulated	Metastatic tissues	Yoshida et al., 2013
	Endometrial cancer	Downregulated	Metastatic tissues	Yoshida et al., 2013
	Hepatic cancer	Phosphorylation	Tumorigenesis	Leung et al., 2011

*Induced by LPS via NF-κB pathway.

**Upregulated by TGF-β-Smad4-dependent pathway.