Table 2.

Meta-analysis on suicidality in patients who underwent DBS.

References	Disease and sample size	Study design	Completed suicides	SA	SI
Kleiner-Fisman et al. (2006)	PD 971	Meta-analysis (1993–2004)	0.1%	0.7%	N/A
Appleby et al. (2007)	EMD 10399	Meta-analysis (1996–2005)	0.16–0.32%	0.3–0.7%*	0.3–0.7%*
Du et al. (2020)	PD	Meta-analysis (1990–2019)	(a) DBS vs. drug therapy: No significant differences; (b) DBS vs. general population: Significant increased risk of suicide and/or SI (OR = 2.839–3.927, p< 0.0001).
Xu et al. (2021)	PD	Meta-analysis (all eligible studies till 2019)	1%	1%	4%

DBS, Deep Brain Stimulation; EMD, extrapyramidal movement disorder; N/A, unavailable; PD, Parkinson’s Disease; SA, suicidal attempt, SI, suicidal ideation. *SA and SI considered together as “suicidality”.