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. 2021 Apr 8;13:645258. doi: 10.3389/fnagi.2021.645258

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Copyright © 2021 Callow, Won, Pena, Jordan, Arnold-Nedimala, Kommula, Nielson and Smith.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Change in gray matter (GM) diffusivity was positively associated with improved verbal fluency and episodic memory performance. (A) Residualized change in verbal fluency (COWAT, Controlled Oral Word Association Test) scores were significantly related to residualized change in left insular MD values, controlling for age. (B) Residualized change in rey auditory verbal learning test (RAVLT) Trial 1 scores were significantly related to residualized change in left cerebellar MD values, controlling for age. The two groups are healthy controls (HC; black symbols) and those diagnosed with Mild Cognitive Impairment (MCI; gray symbols). Gray shaded region represents 95% confidence interval.