Table 3.
Significant mean diffusivity values for the Group, Time, and Group × Time voxel-wise analysis clusters.
| Cluster | Cluster region | Peak location | Volume | MCI (n = 15) | HC (n = 17) | ||||
|---|---|---|---|---|---|---|---|---|---|
| x | y | z | (voxels) | Before | After | Before | After | ||
| Group × Time Interaction | |||||||||
| 1 | Left Insula | 35.0 | 5.0 | 2.0 | 1,588 | 1.33 (0.18) | 1.45 (0.21) | 1.21 (0.11) | 1.20 (0.14) |
| Time Main Effect | |||||||||
| 2 | Left Cerebellum | 21.0 | 50.0 | −18.0 | 2,184 | 1.10 (0.17) | 1.34 (0.43) | 1.06 (0.15) | 1.12 (0.18) |
| 3 | Left Insula | 35.0 | −5.0 | 1.0 | 2,127 | 1.34 (0.18) | 1.46 (0.21) | 1.20 (0.13) | 1.21 (0.15) |
| 4 | Right Cerebellum | −23.0 | 54.0 | −18.0 | 1,199 | 1.68 (0.19) | 1.40 (0.41) | 1.10 (0.15) | 1.17 (0.16) |
| Group Main Effect | |||||||||
| 5 | Right Temporal Lobe | −55.0 | 0.0 | −13.0 | 1,976 | 1.30 (0.12) | 1.31 (0.14) | 1.14 (0.09) | 1.12 (0.10) |
| 6 | Right Insula | −38.0 | −2.0 | 5.0 | 1,525 | 1.37 (0.14) | 1.44 (0.25) | 1.21 (0.15) | 1.19 (0.10) |
| 7 | Left Insula | 32.0 | −3.0 | 8.0 | 1,159 | 1.27 (0.18) | 1.36 (0.19) | 1.12 (0.12) | 1.11 (0.16) |
Notes. Mean and standard deviations of raw mean diffusivity values extracted from significant family-wise error corrected Group, Time, and Group × Time clusters. Clusters produced using AFNI’s 3dLME procedure for a voxel-wise analysis, after adjusting for age. Regions are defined by the highest probability using the MNI Structural Atlas.