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. 2021 Apr 8;9:640169. doi: 10.3389/fcell.2021.640169

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Copyright © 2021 Siems, Jahn, Hoodless, Jung, Hesse, Möbius, Czopka and Werner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of myelin-related mRNAs in OPCs and mature oligodendrocytes. Violin plots comparing the relative abundance of selected myelin-related transcripts in OPCs and mature oligodendrocytes according to a previously established scRNAseq dataset (Marisca et al., 2020). Data are given as normalized log-transformed mRNA abundance in transcripts per million (TPM) in OPCs (gray) versus mature oligodendrocytes (mOL) (green). Median with interquartile ranges; n = 189 OPCs (combined clusters 1–4 in Marisca et al., 2020) versus n = 19 mOL (cluster 5 in Marisca et al., 2020); ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001 by Welch’s t-test. For precise p-values, see section “Materials and Methods.” The mRNAs for oligodendrocyte transcription factor 2 (olig2), myelin regulatory factor (myrf), and SRY-box transcription factor 10 (sox10) serve as markers. ns, not significant.