Fig. 3.

Nrf2/ARE pathway was activated in ox-LDL-treated macrophages during autophagy blockage. (a) Western blotting in each of the following treatment groups: control, ox-LDL (75 μg/mL), and ox-LDL+CQ (50 μM). (b, c, d, e) Expression of p62, LC3II/I, HO-1 and Nrf2 under each groups. (f) mRNA levels of HO-1 and Nrf2 were showed by qRT-PCR. Values are expressed as the mean ± SEM (n = 3) of independent experiments at least 3 repeated measurements. ^*p < 0.05 and ^**p < 0.01 different from the control group, ^#p < 0.05 and ^##p < 0.01 different from the ox-LDL-treated group