Table 2.
Overrepresented KEGG and WP Pathways Based on ≥2 PSEA-Decomposed Differentially Expressed Genes between Periodontitis-Affected and Healthy Gingival Tissues, by Cell Type.
| Pathway | Pathway ID | Adjusted P Value | Genes |
|---|---|---|---|
| Epithelial cells | |||
| Th17 cell differentiation | KEGG:04659 | 0.03031515 | RORA, MAPK13, TGFB1 |
| AGE-RAGE signaling pathway in diabetic complications | KEGG:04933 | 0.03031515 | COL4A2, MAPK13, TGFB1 |
| Relaxin signaling pathway | KEGG:04926 | 0.03701637 | COL4A2, MAPK13, TGFB1 |
| Pathogenic Escherichia coli infection | KEGG:05130 | 0.09286103 | OCLN, MAPK13, TUBB2A |
| Inflammatory bowel disease (IBD) | KEGG:05321 | 0.09286103 | RORA, TGFB1 |
| Epithelial to mesenchymal transition in colorectal cancer | WP:WP4239 | 0.00876677 | COL4A2, OCLN, MAPK13, TGFB1 |
| Cannabinoid receptor signaling | WP:WP3869 | 0.04737078 | MAPK13, CYP2C9 |
| Hepatitis C and hepatocellular carcinoma | WP:WP3646 | 0.06769704 | COL4A2, TGFB1 |
| Pathogenic Escherichia coli infection | WP:WP2272 | 0.06769704 | OCLN, TUBB2A |
| Fibroblasts | |||
| VEGFA-VEGFR2 signaling | WP:WP3888 | 0.04963475 | CALU, MMP14, PBXIP1 |
| Senescence and autophagy in cancer | WP:WP615 | 0.04963475 | IGFBP5, MMP14 |
| Endothelial cells | |||
| Fat digestion and absorption | KEGG:04975 | 0.05687131 | AGPAT1, SCARB1 |
| Sterol regulatory element-binding proteins (SREBP) signaling | WP:WP1982 | 0.060402348 | SEC24A, SCARB1 |
| Neutrophils | |||
| Human complement system | WP:WP2806 | 0.080752415 | SELPLG, LAMC1 |
| Nuclear receptors meta-pathway | WP:WP2882 | 0.080752415 | PPP1R14C, DBI, CYP2C9 |
| Plasma cells | |||
| Protein processing in endoplasmic reticulum | KEGG:04141 | 0.005626135 | WFS1, RRBP1, PREB |
| B cells | |||
| Human cytomegalovirus infection | KEGG:05163 | 0.071917892 | IL10RA, GNG7, TAPBP |
PSEA, population-specific expression analysis.