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. 2021 Apr 20;100(5):542–548. doi: 10.1177/0022034520979150

Figure 2.

Figure 2.

The Streptococcus sobrinus ComRS gene cluster is distinct from other streptococci. (A) The ComRS gene cluster in strains NIDR 6715-7 and SL1 contain 2 homologs of comR that we call comR1 and comR2. The type strain SL1 contains a truncated comR2 gene (green/white) and cannot be transformed. Strain NCTC 10919 has a single homolog of comR and no comS gene or a ComS export/cleavage gene. (B) Strain NIDR 6715-7 cannot be transformed if comR2 or the region from comR1 to comR2 is deleted. An additional copy of comR1 on a plasmid does not rescue transformation, but strains complemented with extra comR2 can be transformed. The horizontal bars represent the mean of the biological replicates (black dots). (C) The single comR homolog in strain NCTC 10919 is required for transformation. (D) The comR gene in strain NCTC 10919 appears to be a fusion of comR1 and comR2. A recombination event that produced comR would have removed the premature stop codon found in the comR2 gene of strain SL1.