Table 4.

Differential metabolites of serum between patients with ESRD and healthy controls

Metabolic Pathway	Metabolites	Mean (ESRD)	Mean (HC)	Fold change	Log_fold change	AUC value
Glycine, serine, and threonine metabolism	Glycine	1.9834	0.6171	3.214	1.684	0.972
	l-Serine	1.3163	0.1549	8.497	3.087	0.995
	l-Allothreonine	3.0007	0.4912	6.109	2.611	0.971
Phenylalanine metabolism	l-Phenylalanine	46.5813	19.7719	2.356	1.236	0.975
	ortho-Hydroxyphenylacetic acid	15.8486	0.3832	41.359	5.370	1.000
	Phenylacetic acid	15.8486	0.3832	41.359	5.370	0.997
	Phenylacetylglutamine	174.1466	0.9897	175.951	7.459	1.000
	4-Hydroxybenzoic acid	13.9005	0.0890	156.181	7.287	1.000
	p-Hydroxyphenylacetic acid	2.1442	0.0570	37.632	5.234	0.993
Pyrimidine metabolism	Cytosine	2.0971	0.1987	10.556	3.400	1.000
	Deoxyribose 1-phosphate	542.9885	12.8789	42.161	5.398	0.983
	Uracil	6.0958	1.5430	3.951	1.982	0.995
	Pseudouridine	34.0287	1.6156	21.063	4.397	1.000
Arginine and proline metabolism	Creatinine	75.2642	2.7376	27.493	4.781	1.000
	Citrulline	4.3835	0.0979	44.772	5.485	1.000
	l-Proline	38.7071	12.2175	3.168	1.664	0.975
	4-Hydroxyproline	4.1395	0.5685	7.281	2.864	0.970
	4-Acetamidobutanoic acid	10.1351	0.0577	175.635	7.456	1.000
	N-Acetylglutamic acid	0.9101	0.0517	17.611	4.138	1.000

ESRD, end-stage renal disease; HC, healthy controls; AUC, area under curve