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. 2021 Apr 22;52(3):779–781. doi: 10.1007/s11239-021-02454-y

Table 1.

Comparison between patients during the first and second pandemic wave

Characteristics 1st pandemic wave (n = 247) 2nd pandemic wave (n = 142) P-value
Demographic and clinical characteristics
 Mean age, years ± SD 65.3 ± 15.4 71.4 ± 14.0 0.47
 Men, n (%) 160 (65.0%) 83 (58.0%) 0.21
 Hypertension, n (%) 115 (46.5%) 88 (61.9%) 0.003
 Diabetes, n (%) 32 (12.9%) 32 (22.5%) 0.01
 Ischemic cardiovascular diseases, n (%) 29 (11.7%) 31 (21.8%) 0.007
 VTE, n (%) 4 (1.6%) 3 (2.1%) 0.72
 COPD, n (%) 20 (8.0%) 10 (7.0%) 0.70
Laboratory and clinical results during hospitalization
 Mean D-dimers, ng/ml ± SD 3585.0 ± 7172.2 1748.1 ± 3417.5 0.02
 Mean C-reactive protein, mg/L ± SD 93.2 ± 77.6 74.1 ± 67.4 0.07
 Mean leukocytes, cell/mmc ± SD 6943.5 ± 3187.4 8811.2 ± 3767.4 0.001
 Mean PaO2/FiO2, ratio ± SD 292.2 ± 84.6 284.1 ± 77.6 0.16
 Time from symptoms to D-dimer measurement, days ± SD 7.2 ± 4.0 4.9 ± 4.2  < 0.001
 qCSI, mean ± SD 2.1 ± 3.3 4.4 ± 4.3  < 0.001
 Deaths, n (%) 39 (15.7%) 20 (14.0%) 0.65
 Hospital length in subject who died, days ± SD 14.5 ± 11.4 16.2 ± 14.3 0.30
Pre-admission therapy
 Anticoagulant, n (%) 14 (5.6%) 60 (42.2%)  < 0.00001
 Steroids, n (%) 7 (2.8%) 54 (38.0%)  < 0.00001
 Anticoagulant AND steroids, n (%) 2 (0.8%) 31 (21.8%)  < 0.00001
 Anticoagulant OR steroid, n (%) 19 (7.7%) 83 (58.4%)  < 0.00001