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. 2021 Apr 9;23(6):439. doi: 10.3892/mmr.2021.12078

Figure 2.

Figure 2.

Propofol inhibits the proliferation and migration of bladder cancer cells by regulating miR-145-5p expression. (A) J82 and T24 cells were transduced with anti-miR-145-5p, anti-miR-NC, EV or miR-145-5p, then the relative expression of miR-145-5p was evaluated via RT-qPCR. (B) J82 and (C) and T24 cells were transduced with anti-miR-145-5p, anti-miR-NC or miR-145-5p and exposed to 10 µg/ml propofol, then relative miR-145-5p expression was evaluated via RT-qPCR. (D) J82 and (E) T24 cells were transduced with anti-miR-145-5p, anti-miR-NC or miR-145-5p and exposed to 10 µg/ml propofol, then cell viability was evaluated at 24, 48 and 72 h post-drug treatment. (F) J82 and (G) T24 cells were transduced with anti-miR-145-5p, anti-miR-NC or miR-145-5p and exposed to 10 µg/ml propofol, then cells were used for wound-healing assays. Scale bar, 500 µm. Each assay was performed in triplicate and data are presented as the mean ± SD. *P<0.05. miR, microRNA; NC, negative control; EV, empty vector; RT-qPCR, reverse transcription-quantitative PCR.