Table 2:

Trials in Progress Comparing Primary Treatment Modalities

Title	Phase	Interventions	Enrollment	Estimated Completion	Primary Outcome Measure(s)	NCT#	Study Sponsor
A Randomized Trial of Treatment De-Escalation for HPV-Associated Oropharyngeal Squamous Cell Carcinoma Radiotherapy vs. Trans-Oral Surgery (ORATORIO II)	2	De-escalated primary CRT (60 Gy +/− cisplatin) is compared with transoral surgery, neck dissection and adjuvant RT (50–60 Gy, depending on risk)	140	2028	Overall Survival	NCT03210103	Lawson Health Research Institute
Quality of Life After Primary Transoral Robotic Surgery vs Intensity-modulated Radiotherapy for Patients With Early-stage Oropharyngeal Squamous Cell Carcinoma: A Randomized National Trial (QoLATI)	2	TORS, neck dissection +/− CRT is compared with primary CRT.	138	2029	Swallowing related quality of life (MDADI)	NCT04124198	Christian von Buchwald
Phase III Study Assessing The “Best of” Radiotherapy Compared to the “Best of” Surgery (Trans-oral Surgery (TOS)) in Patients With T1-T2, N0 Oropharyngeal Carcinoma	3	Transoral surgery and neck dissection is compared with RT and neck dissection	170	2026	Change in MDADI scores	NCT02984410	European Organization for Research and Treatment of Cancer (EORTC)
Comparative Effectiveness Trial of Transoral Head and Neck Surgery Followed by Adjuvant Radio(Chemo)Therapy Versus Primary Radiochemotherapy for Oropharyngeal Cancer	4	Transoral surgery, neck dissection +/− CRT is compared with primary CRT	280	2023	Time to local or locoregional failure or death from any cause	NCT03691441	Universitätsklinikum Hamburg-Eppendorf

Data from clinicaltrials.gov; Abbreviations- RT: radiation therapy, CRT: chemoradiation therapy, Gy: Gray, MDADI:MD Anderson Dysphagia Inventory