Table 6.

Exploratory “DOOR” endpoint with partial credit [19]

Composite	Score
Dead within 14 days of randomisation	0
Dead within 30 days of randomisation	10
Dead within 30 days, and with C. difficile or carbapenem-resistant Enterobacterales (CRE) during the time from randomisation to death	20
Dead within 30 days, but without C. difficile or CRE during the time from randomisation to death	30
Alive at 30 days, but with deterioration in functional status, and with C. difficile or CRE	50–65*
Alive at 30 days, but with deterioration in functional status, but no C. difficile or CRE	70–85*
Alive at 30 days, return to baseline functional status but with C. difficile or CRE	90
Alive at 30 days, return to baseline functional status and no C. difficile or CRE	100

*5 point penalty for each decrement in functional bacteremia score (e.g. 85 = 1 FBS score decrement in a participant without C. difficile or CRE, 80 = decrement of 2 on FBS, 75 = decrement of 3 on FBS, 70 = decrement of 4 or more on FBS)