Table 3.

Fifteen most significant differentially methylated CpGs associated with HDI inhalation and skin exposure in 20 automotive spray-painters [Model (2); see Supplementary materials, Table 1 for complete list].

Name	Coordinate	Betaa ± STD	Gene	Chr	CPG islands	Relation	Enhancer	Regulatory	p-value	FDR
cg01877524	117156569	0.983 ± 0.009	DSCAML1	11	117651216–117651429	Island	No		1.33 × 10−11	1.08 × 10−6
cg18321631	151118586	0.052 ± 0.009	ATOX1	5	151137992–151138418	Island	No	Promoter	1.31 × 10−8	0.00091
cg10115148	2862768	0.648 ±0.050		1	2876545–2876808	N_Shelf	No		1.26 × 10−7	0.00762
cg27369325	97760076	0.961 ± 0.009	FARP1	13			Yes		2.31 × 10−7	0.01204
cg12813323	13716491	0.011 ±0.005	FAM210A; RNMT	18	13725979–13727370	Island	No	Promoter	2.48 × 10−7	0.01204
cg16411204	101369803	0.064 ±0.008	SLC25A28	10	101379708–101381445	Island	No		3.85 × 10−7	0.01550
cg27484662	75227180	0.973 ±0.015	ATP9B	18	77125676–77125885	S_Shore	Yes		4.25 × 10−7	0.01550
cg23576507	20641684	0.046 ± 0.010	ZNF219; TMEM253	14	21571835–21572520	Island	No	Promoter	4.27 × 10−7	0.01550
cg17345081	142451632	0.109 ±0.025	NMBR	6	142409473–142410112	Island	No		4.82 × 10−7	0.01550
cg19951424	86983212	0.073 ± 0.008	ISG20	15			No	Promoter	4.95 × 10−7	0.01550
cg03895392	72213387	0.124 ±0.014	ISLR2	15	74425091–74428821	Island	No		5.11 × 10−7	0.01550
cg09949666	43645491	0.882 ± 0.031	COA1	7			No		5.61 × 10−7	0.01603
cg25090499	24941165	0.097 ± 0.012	ATP8A2	13	26042693–26043486	Island	No		7.12 × 10−7	0.01877
cg14931122	19999698	0.070 ±0.010	CYTSB	17	20059028–20060060	Island	No	Unclassified	7.40 × 10−7	0.01877
cg15966253	23822484	0.039 ±0.007	UBE2E1	3	23847871–23848633	N_Shore	No	Promoter	7.73 × 10−7	0.01877

STD: standard deviation.

Chr: chromosome.

FDR: false discovery rate.

^aBeta-value = the average percent methylation measured for the CpG and the standard deviation in the 20 spray-painters.