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The PK profiles of epacadostat (INCB024360)
| Species | CL (L/h/kg) | Vss (L/kg) | iv t1/2 (h) | AUC (μM h) | F (%) | t1/2 (h) |
|---|---|---|---|---|---|---|
| Rat | 1.1 | 2.0 | 1.4 | 1.3 | 11 | 2.2 |
| Dog | 0.5 | 0.7 | 3.1 | 29 | 59 | 4.9 |
| Cyno | 0.8 | 1.8 | 3.3 | 9.3 | 33 | 2.7 |
CL, plasma clearance; Vss, volume distribution stead state; t1/2, half-life; AUC, area under the concentration-time curve; F, Oral bioavailability; iv, intravenous injection; Cyno, cynomologous monkeys
