Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The PK profiles of navoximod
| Species | CL (mL/min/kg) | Cmax (ng/mL) | t1/2 (h) | F (%) | AUC (ng h/mL) |
|---|---|---|---|---|---|
| Rat | 44.6 | 1560 | 1.44 | 41.5 | 3930 |
| Mice | 27.5 | 2257 | 3.9 | 69.0 | 6132 |
| Dog | 53.7 | 1400 | 4.8 | 22.3 | 3127 |
CL, Plasma clearance; Cmax, peak concentration; t1/2, half-life; F, Oral bioavailability; AUC, area under the concentration-time curve
