Table 6.
Comparison of pharmacokinetics after a single dose of 5 or 6 in mice
| Compound | Dose (μM/kg) | Cmax (μM) | AUC0–24 (μM h) | t1/2 (h) |
|---|---|---|---|---|
| Indoximod (5) | 143 | 9.3 ± 2.2 | 36.4 ± 9 | 3 |
| 287 | 17.2 ± 3.7 | 77.7 ± 21.6 | 2.8 | |
| 573 | 26 ± 11.1 | 153.6 ± 79.2 | 3.1 | |
| 1147 | 51.7 ± 25.4 | 348.2 ± 115.2 | 3.4 | |
| NLG802 (6) | 143 | 35 ± 25.3 | 105.4 ± 68.5 | 2.9 |
| 287 | 68.9 ± 3.9 | 142.3 ± 64.6 | 2.2 | |
| 573 | 65.7 ± 34.1 | 150.8 ± 76.1 | 3.1 | |
| 1147 | 101.4 ± 38.9 | 374.3 ± 180.7 | 3.2 |
Cmax, maximum concentration observed in plasma; AUC0–24, area under the plasma concentration-time curve from 0 to 24 h of quantifiable concentration; t1/2, half-life