Table 1.
Clinical and molecular characteristics of patients with pediatric acute T-ALL with respect to BRD4 expression
| High BRD4 expression | Low BRD4 expression | P-Value | |
|---|---|---|---|
| Gender, n (%) | 0.409 | ||
| Male | 26 (57) | 12 (26) | |
| Female | 7 (15) | 1 (2) | |
| Age at diagnosis,years,median (range) | 7.6 (2.3–11.6) | 7.9 (1.2–12.2) | 0.232 |
| Hemoglobin, g/L, median (range) | 102 (54–152) | 105 (49–115) | 0.518 |
| Platelet, (× 109/L), median (range) | 78 (10–263) | 65 (30–206) | 0.634 |
| Initial BM blast (%) | 87 (24–100) | 92 (71–97) | 0.191 |
| Initial WBC, (× 109/L), n (%) | 1.000 | ||
| < 100 | 14 (31) | 5 (11) | |
| ≥ 100 | 19 (4) | 8 (17) | |
| Prednisone Response, n (%) | 0.738 | ||
| Good | 12 (26) | 6 (13) | |
| Poor | 21 (46) | 7 (15) | |
| Day 15th BM, n (%) | 0.675 | ||
| M1 + M2 | 20 (43) | 7 (15) | |
| M3 | 13 (28) | 6 (14) | |
| D33th BM blast, n (%) | 1.000 | ||
| M1 | 29 (63) | 11 (24) | |
| M2 | 4 (9) | 2 (4) | |
| Week 12th BM blast, n (%) | 0.548 | ||
| M1 | 30 (65) | 13 (28) | |
| M2 | 3 (7) | 0 (0) | |
| Risk group, n (%) | 0.385 | ||
| Intermediate risk | 29 (63) | 10 (22) | |
| High risk | 4 (9) | 3 (6) | |
| Relapse, n (%) | |||
| Yes | 12 (26) | 2 (4) | 0.286 |
| No | 21 (46) | 11 (24) | |
| Survival times | |||
| 5-years OS, cumulative survival | 0.480 ± 0.08 | 0.846 ± 0.100 | 0.045 |
| 5-years RFS,cumulative survival | 0.577 ± 0.094 | 0.833 ± 0.108 | 0.155 |