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. 2021 Apr 21;21:444. doi: 10.1186/s12885-021-08172-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Box plot illustration of TACSTD2 methylation and its association with clinicopathological characteristics. The box plot illustrates the median, the estimated confidence intervals, and the 25% quartiles in both groups. Presentation of the natural logarithm of relative methylation of metastasis negative (M0) versus metastasis positive (M1) tumors (a), lymph node negative (N0) versus lymph node positive (N1) tumors (b), low (defined as T1 and T2) versus high (defined as T3 and T4) tumor stage (c) and localized (Loc. defined as pT ≤ 2, N0, M0) versus advanced disease (Adv. defined as pT ≥ 3 and/or N1, M1) (d). Statistical analyses showed significant higher methylation levels in metastasis positive tumors, high tumor stage and advanced disease (Table 2)