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. 2021 Apr 22;22:116. doi: 10.1186/s13059-021-02335-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Genetic contributions to methylation variability. a Example of a SNP associated with altered methylation within MYO3A showing average methylation values for each genotype (indicated) for all tissues. The VMRs associated with this SNP are shaded pink and the SNP is indicated. b Heatmap representing log2 enrichment of CpGs within VMRs and tissue-specific VMRs compared to the rest of the genome for previously published mQTL datasets [6, 51, 52], neuronal VMRs [35], and correlated regions of systemic interindividual variations (CoRSIVs) [36]. Only significant enrichments/depletions are shown; non-significant combinations are shaded gray