Table 3.

CpGs differentially methylated in association with prevalent myocardial infarction in the fixed-effects meta-analyses of the REGICOR case–control samples

Genomic information				Model 1			Model 2			Model 3
CpG	Chr*	Position (bp)	Gene	Coef*	SE*	P	Coef*	SE*	P	Coef*	SE*	P
cg15724772	1	6,373,534	ACOT7	1.17	1.94 × 10–1	1.76 × 10–9	1.16	2.17 × 10–1	8.14 × 10–8	1.00	2.30 × 10–1	1.38 × 10–5
cg11919692	1	26,343,868	Intergenic	1.08	1.98 × 10–1	4.94 × 10–8	1.11	2.19 × 10–1	4.00 × 10–7	1.04	2.34 × 10–1	9.29 × 10–6
cg10636246	1	159,046,973	AIM2	− 0.96	1.41 × 10–1	1.03 × 10–11	− 0.98	1.58 × 10–1	5.21 × 10–10	− 0.86	1.68 × 10–1	3.68 × 10–7
cg08345526	1	226,916,320	ITPKB	1.79	2.93 × 10–1	1.02 × 10–9	1.85	3.29 × 10–1	1.71 × 10–8	1.60	3.45 × 10–1	3.42 × 10–6
cg01552966	2	25,528,330	DNMT3A	1.15	1.93 × 10–1	2.43 × 10–9	1.25	2.22 × 10–1	1.78 × 10–8	1.04	2.33 × 10–1	7.66 × 10–6
cg25420477	2	70,319,121	Intergenic	1.54	2.52 × 10–1	1.08 × 10–9	1.63	2.84 × 10–1	9.01 × 10–9	1.47	3.01 × 10–1	9.45 × 10–7
cg06528771	2	102,513,985	Intergenic	− 1.71	2.79 × 10–1	9.88 × 10–10	− 1.89	3.16 × 10–1	2.26 × 10–9	− 1.81	3.48 × 10–1	1.81 × 10–7
cg12206840	2	136,826,451	Intergenic	1.12	1.98 × 10–1	1.31 × 10–8	1.12	2.23 × 10–1	4.89 × 10–7	1.03	2.33 × 10–1	9.08 × 10–6
cg21566642	2	233,284,661	Intergenic	− 0.65	1.13 × 10–1	7.70 × 10–9	− 0.30	1.56 × 10–1	5.26 × 10–2	− 0.41	1.70 × 10–1	1.50 × 10–2
cg10650214	3	45,914,188	LZTFL1	1.28	1.97 × 10–1	8.01 × 10–11	1.26	2.19 × 10–1	8.05 × 10–9	1.18	2.31 × 10–1	2.99 × 10–7
cg07386061	3	52,492,874	NISCH	0.99	1.79 × 10–1	2.86 × 10–8	1.03	2.01 × 10–1	3.27 × 10–7	0.86	2.09 × 10–1	4.01 × 10–5
cg13373048	3	71,892,575	Intergenic	− 2.76	3.57 × 10–1	1.02 × 10–14	− 3.24	4.23 × 10–1	1.93 × 10–14	− 3.03	4.29 × 10–1	1.77 × 10–12
cg03733470	3	196,613,114	SENP5	− 1.20	2.07 × 10–1	5.94 × 10–9	− 1.28	2.30 × 10–1	2.70 × 10–8	− 1.17	2.46 × 10–1	2.01 × 10–6
cg05575921	5	373,378	AHRR	− 0.75	1.25 × 10–1	2.05 × 10–9	− 0.40	1.91 × 10–1	3.48 × 10–2	− 0.45	2.04 × 10–1	2.87 × 10–2
cg25769469	5	71,643,841	PTCD2	− 1.33	2.20 × 10–1	1.33 × 10–9	− 1.38	2.53 × 10–1	5.40 × 10–8	− 1.41	2.80 × 10–1	4.92 × 10–7
cg04725636	8	67,004,538	DNAJC5B	− 0.80	1.45 × 10–1	3.33 × 10–8	− 0.72	1.59 × 10–1	5.47 × 10–6	− 0.751	1.74 × 10–1	1.76 × 10–5
cg12066594	9	127,162,066	PSMB7	− 1.89	3.37 × 10–1	2.00 × 10–8	− 2.57	4.07 × 10–1	2.67 × 10–10	− 2.36	4.25 × 10–1	2.83 × 10–8
cg24501073	11	34,210,305	ABTB2	0.99	1.73 × 10–1	1.07 × 10–8	0.98	1.96 × 10–1	6.11 × 10–7	0.82	1.98 × 10–1	3.07 × 10–5
cg02042026	11	113,936,782	ZBTB16	1.04	1.70 × 10–1	8.50 × 10–10	0.99	1.88 × 10–1	1.51 × 10–7	0.98	2.04 × 10–1	1.50 × 10–6
cg01381203	12	2,985,630	FOXM1;RHNO1	− 0.88	1.62 × 10–1	5.17 × 10–8	− 0.84	1.76 × 10–1	1.88 × 10–6	− 0.92	1.95 × 10–1	2.44 × 10–6
cg02175213	12	69,352,407	CPM	− 1.08	1.85 × 10–1	5.15 × 10–9	− 1.10	2.06 × 10–1	9.76 × 10–8	− 0.82	2.14 × 10–1	1.27 × 10–4
cg06084585	13	50,797,125	DLEU1	− 1.60	2.87 × 10–1	2.37 × 10–8	− 1.47	3.14 × 10–1	2.96 × 10–6	− 1.36	3.30 × 10–1	3.54 × 10–5
cg15867698	14	69,438,267	ACTN1	1.13	1.86 × 10–1	1.58 × 10–9	1.26	2.14 × 10–1	3.33 × 10–9	1.14	2.25 × 10–1	4.04 × 10–7
cg07252680	14	94,857,224	SERPINA1	− 1.56	2.41 × 10–1	1.17 × 10–10	− 1.43	2.65 × 10–1	6.57 × 10–8	− 1.41	2.86 × 10–1	7.93 × 10–7
cg16125725	15	70,101,302	Intergenic	− 2.03	3.45 × 10–1	4.02 × 10–9	− 2.30	3.97 × 10–1	6.82 × 10–9	− 2.20	4.18 × 10–1	1.39 × 10–7
cg09967176	15	77,280,925	Intergenic	− 1.28	1.78 × 10–1	6.93 × 10–13	− 1.40	2.03 × 10–1	5.21 × 10–12	− 1.16	2.10 × 10–1	3.82 × 10–8
cg17261469	16	87,420,879	FBXO31	0.99	1.73 × 10–1	9.49 × 10–9	1.00	1.94 × 10–1	3.01 × 10–7	1.00	2.04 × 10–1	9.92 × 10–7
cg04983687	16	88,558,223	ZFPM1	0.72	1.29 × 10–1	2.61 × 10–8	0.68	1.42 × 10–1	1.79 × 10–6	0.44	1.46 × 10–1	2.49 × 10–3
cg22508829	17	17,843,585	TOM1L2	1.28	1.96 × 10–1	7.97 × 10–11	1.35	2.26 × 10–1	2.41 × 10–9	1.10	2.28 × 10–1	1.23 × 10–6
cg22146772	17	26,793,673	Intergenic	1.23	1.97 × 10–1	5.38 × 10–10	1.18	2.22 × 10–1	8.98 × 10–8	1.06	2.28 × 10–1	3.31 × 10–6
cg13064873	17	48,360,726	TMEM92− AS1	− 1.08	1.85 × 10–1	5.31 × 10–9	− 1.19	2.12 × 10–1	1.82 × 10–8	− 1.04	2.23 × 10–1	3.19 × 10–6
cg04988978	17	56,359,578	MPO	− 1.31	2.07 × 10–1	2.33 × 10–10	− 1.45	2.37 × 10–1	9.71 × 10–10	− 1.22	2.43 × 10–1	5.41 × 10–7
cg03636183	19	17,000,585	F2RL3	− 0.74	1.36 × 10–1	4.56 × 10–8	− 0.35	1.80 × 10–1	5.24 × 10–2	− 0.39	1.90 × 10–1	4.12 × 10–2
cg19448292	20	35,504,064	C20orf118	1.24	1.93 × 10–1	1.17 × 10–10	1.38	2.25 × 10–1	7.89 × 10–10	1.15	2.30 × 10–1	6.05 × 10–7

*Chr, Chromosome; Coef; Coefficient of association; SE, Standard error

Model 1 was adjusted for estimated cell counts and two surrogate variables. Model 2 was further adjusted for smoking status. Model 3 was additionally adjusted for diabetes, hypercholesterolemia, and hypertension. The Bonferroni-corrected p threshold was 6.17 × 10^–8