Table 4.

CpGs differentially methylated in association with incident coronary/cardiovascular disease in the fixed-effects meta-analyses of the samples from the Women’s Health Initiative (WHI) and the Framingham Offspring Study (FOS)

Genomic information				Model 1			Model 2			Model 3
CpG	Chr*	Position (bp)	Gene	Coef*	SE*	P	Coef*	SE*	P	Coef*	SE*	P
Incident coronary heart disease
cg21566642	2	233,284,661	Intergenic	− 1.34 × 10–1	4.33 × 10–2	2.00 × 10–3	− 9.63 × 10–2	4.83 × 10–2	4.62 × 10–2	− 9.66 × 10–2	5.39 × 10–2	7.32 × 10–2
cg05575921	5	373,378	AHRR	− 1.80 × 10–1	4.73 × 10–2	1.38 × 10–4	− 1.33 × 10–1	5.81 × 10–2	2.21 × 10–2	− 1.22 × 10–1	6.52 × 10–2	6.05 × 10–2
cg25769469	5	71,643,841	PTCD2	− 2.62 × 10–1	7.94 × 10–2	9.67 × 10–4	− 2.52 × 10–1	8.02 × 10–2	1.70 × 10–3	− 2.14 × 10–1	8.89 × 10–2	1.59 × 10–2
cg04988978	17	56,359,578	MPO	− 2.28 × 10–1	7.49 × 10–2	2.29 × 10–3	− 2.07 × 10–1	7.58 × 10–2	6.19 × 10–3	− 1.06 × 10–1	8.35 × 10–2	2.03 × 10–1
Incident cardiovascular disease
cg21566642	2	233,284,661	Intergenic	− 1.68 × 10–1	3.97 × 10–2	2.34 × 10–5	− 1.31 × 10–1	4.40 × 10–2	2.94 × 10–3	− 1.37 × 10–1	4.85 × 10–2	4.87 × 10–3
cg05575921	5	373,378	AHRR	− 2.08 × 10–1	4.30 × 10–2	1.30 × 10–6	− 1.67 × 10–1	5.24 × 10–2	1.42 × 10–3	− 1.61 × 10–1	5.79 × 10–2	5.54 × 10–3
cg25769469	5	71,643,841	PTCD2	− 1.92 × 10–1	7.27 × 10–2	8.40 × 10–3	− 1.77 × 10–1	7.35 × 10–2	1.58 × 10–2	− 1.26 × 10–1	8.09 × 10–2	1.20 × 10–1
cg04988978	17	56,359,578	MPO	− 2.04 × 10–1	6.72 × 10–2	2.42 × 10–3	− 1.83 × 10–1	6.79 × 10–2	6.99 × 10–3	− 9.08 × 10–2	7.36 × 10–2	2.18 × 10–1

*Chr, Chromosome; Coef; Coefficient of association; SE, Standard error

Model 1 was adjusted for age, estimated cell counts and two surrogate variables (plus ancestry in WHI, plus sex in FOS). Model 2 was further adjusted for smoking status. Model 3 was additionally adjusted for diabetes, hypercholesterolemia, and hypertension. The Bonferroni-corrected p threshold was 4.17 × 10^–3